Comment le moine Gregor Mendel élabora-t-il les premières lois de la génétique à travers l'étude des petits pois ? Au nom de quel « crépuscule génétique » la Cour suprême américaine a-t-elle pu autoriser la stérilisation forcée des « faibles d'esprit » ? Et comment expliquer que des jumeaux séparés à la naissance aient tous deux été prénommés Jim par leur famille d'accueil, aient épousé une Linda et engendré un petit James Allan ?En conteur hors pair, Siddhartha Mukherjee s'attelle à percer les mystères du vivant en analysant toutes les facettes du gène, à travers une somptueuse saga entre récit historique, cours de biologie et enquête personnelle.Contient un cahier photos de 8 pages.
La lutte contre le cancer est une histoire humaine : une aventure pleine de découvertes, et une célébration de la ténacité des hommes.Le besoin de connaître ce vieil ennemi est plus fort que jamais. Des premiers traitements chirurgicaux, novateurs mais brutaux, aux travaux des époux Curie sur les radiations ; de la mise au point de la chimiothérapie jusqu'au traitement des patients de l'auteur lui-même, ce livre captivant retrace un combat plusieurs fois centenaire.Dévoilant en un récit exceptionnel le chemin parcouru pour résoudre l'un des grands mystères de la science, Siddhartha Mukherjee offre un aperçu fascinant de nos progrès futurs.
Winner of the Guardian First Book Award 2011 Winner of the Pulitzer Prize for Non-fiction 2011 Shortlisted for the Duff Cooper Prize 2011 Shortlisted for the Wellcome Trust Book Prize
WINNER OF THE PULITZER PRIZEThe Emperor of All Maladies is a magnificent, profoundly humane "biography" of cancer--from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist's precision, a historian's perspective, and a biographer's passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with--and perished from--for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer." The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave may have cut off her diseased breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee's own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive--and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
Siddhartha Mukherjee is a cancer physician and researcher, a stem cell biologist and a cancer geneticist. He is the author of The Laws of Medicine and The Emperor of All Maladies: A Biography of Cancer , which won the 2011 Pulitzer Prize in general nonfiction and the Guardian First Book Award. Mukherjee is an assistant professor of medicine at Columbia University. A Rhodes Scholar, he graduated from Stanford University, University of Oxford, and Harvard Medical School. His laboratory has identified genes that regulate stem cells, and his team is internationally recognized for its discovery of skeletal stem cells and genetic alterations in blood cancers. He has published work in Nature , Cell , Neuron , The New England Journal of Medicine , the New York Times and several other magazine and journals. He lives with his family in New York City.
THE NEW YORK TIMES NUMBER ONE BESTSELLER Spanning the globe and several centuries, this is the remarkable story of the gene and an intimate history of the author's own family, from award-winning author Siddhartha Mukherjee The story begins in an Augustinian abbey in 1856, and takes the reader from Darwin's groundbreaking theory of evolution, to the horrors of Nazi eugenics, to present day and beyond - as we learn to 'read' and 'write' the human genome that unleashes the potential to change the fates and identities of our children.
Majestic in its scope and ambition, The Gene provides us with a definitive account of the epic history of the quest to decipher the master-code that makes and defines humans - and paints a fascinating vision of both humanity's past and future.
"Siddhartha Mukherjee is the perfect person to guide us through the past, present, and future of genome science' Bill Gates 'A thrilling and comprehensive account of what seems certain to be the most radical, controversial and, to borrow from the subtitle, intimate science of our time...Read this book and steel yourself for what comes next' Sunday Times
